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How is methamphetamine different from other stimulants, like cocaine?


Methamphetamine is classified as a psychostimulant as are such other drugs of abuse as amphetamine and cocaine. We know that methamphetamine is structurally similar to amphetamine and the neurotransmitter dopamine, but it is quite different from cocaine. Although these stimulants have similar behavioral and physiological effects, there are some major differences in the basic mechanisms of how they work at the level of the nerve cell. However, the bottom line is that methamphetamine, like cocaine, results in an accumulation of the neurotransmitter dopamine, and this excessive dopamine concentration appears to produce the stimulation and feelings of euphoria experienced by the user. In contrast to cocaine, which is quickly removed and almost completely metabolized in the body, methamphetamine has a much longer duration of action and a larger percentage of the drug remains unchanged in the body. This results in methamphetamine being present in the brain longer, which ultimately leads to prolonged stimulant effects.

Although both methamphetamine and cocaine are psychostimulants, there are differences between them.

Methamphetamine vs. Cocaine

Man-made

Smoking produces a high that lasts 8-24 hours

50% of the drug is removed from the body in 12 hours

Limited medical use

Plant-derived

Smoking produces a high that lasts 20-30 minutes

50% of the drug is removed from the body in 1 hour

Used as a local anesthetic in some surgical procedures

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